Correlation between hydrodynamic radius of protein (Rh) and radius of native protein (Rn)

Range Rh=1.45Rn
Organism Generic
Reference Dill KA, Ghosh K, Schmit JD. Physical limits of cells and proteomes. Proc Natl Acad Sci U S A. 2011 Nov 1 108(44):17876-82 p.17878 right column 3rd paragraphPubMed ID22006304
Primary Source Tyn MT, Gusek TW. Prediction of diffusion coefficients of proteins. Biotechnol Bioeng. 1990 Feb 20 35(4):327-38.PubMed ID18592527
Comments Researchers could adopt the expression for a perfect sphere, Rh=(5/3)^(1/2)Rn~1.3Rn. However, in a survey of native proteins, Tyn and Gusek demonstrated that a better approximation is Rh=1.45Rn (primary source).
Entered by Uri M
ID 107052