In vivo binding dissociation constant for glucocorticoid receptor (GR) at Mouse Mammary Tumor Virus (MMTV) cell

Value ~1E-07 M
Organism Mouse Mus musculus
Reference Sprague BL, Müller F, Pego RL, Bungay PM, Stavreva DA, McNally JG. Analysis of binding at a single spatially localized cluster of binding sites by fluorescence recovery after photobleaching. Biophys J. 2006 Aug 15 91(4):1169-91 p.1183 left column 2nd paragraphPubMed ID16679358
Method FRAP: With ratio k*2on/k2off (of binding site S2)=1.7 combined with an earlier estimate of the number of free binding sites at the MMTV array (Dundr et al., 2002 PMID 12490157) researchers could calculate the above value
Comments Mouse adenocarcinoma cell line 3617. See BNID 106484
Entered by Uri M
ID 106483