Fraction of the endogenous proteome that requires additional assistance in folding from the multisubunit chaperonin GroEL
| Value | 10 % |
|---|---|
| Organism | Bacteria Escherichia coli |
| Reference | Scotto-Lavino E, Bai M, Zhang YB, Freimuth P. Export is the default pathway for soluble unfolded polypeptides that accumulate during expression in Escherichia coli. Protein Expr Purif. 2011 Apr 2 p.1 right column top sentencePubMed ID21443953 |
| Primary Source | Kerner MJ, Naylor DJ, Ishihama Y, Maier T, Chang HC, Stines AP, Georgopoulos C, Frishman D, Hayer-Hartl M, Mann M, Hartl FU. Proteome-wide analysis of chaperonin-dependent protein folding in Escherichia coli. Cell. 2005 Jul 29 122(2):209-20.PubMed ID16051146 |
| Comments | GroEL concentrations in E. coli cells are sufficient to fold about 5% of total cell protein (Lorimer 1996 PMID 8566548) |
| Entered by | Uri M |
| ID | 106325 |