Fraction of breast cancer cases that are hormone receptor-positive and ERBB2-positive

Range 75 to 80 Hormone receptor-positive: 15 to 20 ERBB2-positive %
Organism Human Homo sapiens
Reference Cleator S, Heller W, Coombes RC. Triple-negative breast cancer: therapeutic options. Lancet Oncol. 2007 Mar8(3):235-44. p.235 left column bottom paragraphPubMed ID17329194
Primary Source Konecny G et al., Quantitative association between HER-2/neu and steroid hormone receptors in hormone receptor-positive primary breast cancer. J Natl Cancer Inst. 2003 Jan 15 95(2):142-53 AND Slamon DJ et al., Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer. Science. 1989 May 12 244(4905):707-12.PubMed ID12529347, 2470152
Comments About half of ERBB2-positive cases coexpress hormone receptors. The remaining 10–15% of breast cancers are in a so-called receptor-negative or triple-negative category, as defined by absent expression of these three proteins.
Entered by Uri M
ID 106093