DNA polymerase error rates and the contributions of each fidelity process to mutation rate

Range Figure link - link
Organism Eukaryotes
Reference Kunkel TA. Evolving views of DNA replication (in)fidelity. Cold Spring Harb Symp Quant Biol. 2009 74: 91-101 p. 93 fig.2PubMed ID19903750
Primary Source McCulloch SD, Kunkel TA. The fidelity of DNA synthesis by eukaryotic replicative and translesion synthesis polymerases. Cell Res. 2008 Jan18(1):148-61.PubMed ID18166979
Comments Measurements of the fidelity of DNA synthesis in vitro by purified DNA polymerases reveal a remarkable variation in error rates for the two major types of errors that polymerases generate: single-base-pair substitutions and single-base deletions (Figure link). These error rates reflect the contribution of nucleotide selectivity at the polymerase active site and proofreading by those polymerases harboring an associated 3' exonuclease.
Entered by Uri M
ID 105467