Decrease in glutathione level with age in mouse spleen

Value 21.7 %
Organism Mouse Mus musculus
Reference Richie JP Jr. The role of glutathione in aging and cancer. Exp Gerontol. 1992 Sep-Dec27(5-6):615-26. Table - link PubMed ID1426093
Primary Source Chen TS, Richie JP Jr, Lang CA. Life span profiles of glutathione and acetaminophen detoxification. Drug Metab Dispos. 1990 Nov-Dec18(6):882-7.PubMed ID1981532
Method Researchers' previous finding of a glutathione (GSH) deficiency in aging or senescent mice suggested that a concomitant decrease in detoxification capacity also may occur. To test this, mice at different biological stages of the life span (growth, maturity, aging or senescence) were injected with various doses of acetaminophen (APAP), and GSH depletion and recovery rates were determined. At intervals for 24 hr, samples of blood and other tissues were obtained, processed, and analyzed for reduced GSH, glutathione disulfide (GSSG), cysteine, and cystine using HPLC with dual electrochemical detection.
Comments Table gives values of GSH levels in very old (30-33 month) adult C57BL/6NIA mice as percent of mature (12 month) adult values. See BNIDs 104658, 104659
Entered by Uri M
ID 104660