Decrease in concentration of dolichol in brain of scrapie prion diseased mouse

Value 30 %
Organism Mouse Mus musculus
Reference Guan Z, Söderberg M, Sindelar P, Prusiner SB, Kristensson K, Dallner G. Lipid composition in scrapie-infected mouse brain: prion infection increases the levels of dolichyl phosphate and ubiquinone. J Neurochem. 1996 Jan66(1):277-85 abstract and p.283 left column 3rd paragraphPubMed ID8522965
Method P.279 right column top paragraph: "Extraction of dolichol and dolichyl phosphate was performed after initial alkaline hydrolysis (Low et al., 1991)."
Comments Abstract: "The neutral and phospholipid composition of mouse brain infected with scrapie prions was investigated. During the later stages of this disease, the level of dolichol decreased by 30% whereas the level of dolichyl phosphate increased by 30%." P.283 left column 3rd paragraph: "The dolichol content of brain increases continuously during the whole lifetime of the mouse, but this increase occurred to a much lesser extent in scrapie-infected animals. In the final stage of the disease process, the difference in the dolichol contents of brains from infected and uninfected animals was as much as 30%. Decreased dolichol concentrations have also been found in the brains of patients with Alzheimer’s disease (Soderberg et al., 1992). In model membranes, dolichol has a destabilizing effect and increases both the membrane fluidity and permeability (de Ropp and Troy, 1985, Valtersson et al., 1985)."
Entered by Uri M
ID 103296