Increase in concentration of dolichyl phosphate in brain of scrapie prion diseased mouse

Value 30 %
Organism Mouse Mus musculus
Reference Guan Z, Söderberg M, Sindelar P, Prusiner SB, Kristensson K, Dallner G. Lipid composition in scrapie-infected mouse brain: prion infection increases the levels of dolichyl phosphate and ubiquinone. J Neurochem. 1996 Jan66(1):277-85 abstractPubMed ID8522965
Method P.279 right column top paragraph: "Extraction of dolichol and dolichyl phosphate was performed after initial alkaline hydrolysis (Low et al., 1991)."
Comments Abstract: "The neutral and phospholipid composition of mouse brain infected with scrapie prions was investigated. During the later stages of this disease, the level of dolichol decreased by 30% whereas the level of dolichyl phosphate increased by 30%."
Entered by Uri M
ID 103294