Distance between dinucleotide motifs conferring DNA high affinity binding to nucleosome

Value 10 bp
Organism Generic
Reference Garcia HG, Grayson P, Han L, Inamdar M, Kondev J, Nelson PC, Phillips R, Widom J, Wiggins PA. Biological consequences of tightly bent DNA: the other life of a macromolecular celebrity. Biopolymers. 2007 Feb 585(2):115-30.PubMed ID17103419
Comments The most important DNA sequence motifs that confer high affinity binding to the nucleosome are AA, TT, or TA dinucleotide steps (i.e., an A followed by another A, and so on), which recur every 10 bp, in phase with the DNA helical repeat (every 10.4 bp the DNA helix completes a turn), every time the DNA minor groove (phosphodiester backbone) rotates around to face inward toward the center of curvature of the nucleosomes protein core.
Entered by Uri M
ID 103151