| Reference |
Garcia HG, Grayson P, Han L, Inamdar M, Kondev J, Nelson PC, Phillips R, Widom J, Wiggins PA. Biological consequences of tightly bent DNA: the other life of a macromolecular celebrity. Biopolymers. 2007 Feb 585(2):115-30.PubMed ID17103419
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| Comments |
The most important DNA sequence motifs that confer high affinity binding to the nucleosome are AA, TT, or TA dinucleotide steps (i.e., an A followed by another A, and so on), which recur every 10 bp, in phase with the DNA helical repeat (every 10.4 bp the DNA helix completes a turn), every time the DNA minor groove (phosphodiester backbone) rotates around to face inward toward the center of curvature of the nucleosomes protein core. |