Fraction of B cells arising during fetal development
| Value | 5 % |
|---|---|
| Organism | Various |
| Reference | Charles A. Janeway Jr., Paul Travers, Mark Walport, Mark J. Shlomchik, Immunobiology, 2001 5th edition Garland publishing, chapter 7, the immune system in health and disease [ncbi- electronic resource] section 7.28 link p.272 bottom paragraph |
| Comments | P.272 bottom paragraph: "7-28 The B-1 subset of B cells has a distinct developmental history and expresses a distinctive repertoire of receptors: A minority subset of B cells (comprising about 5%) in mice and humans, and the major population in rabbits, arises during fetal development and has a restricted receptor repertoire (Fig. 7.37). The B cells belonging to this subset were first identified by surface expression of the protein CD5 and are also characterized by high levels of sIgM with little sIgD, even when mature. They are termed B-1 cells, because their development precedes that of the conventional B cells whose development has been discussed up to now and which are sometimes termed B-2 cells." B1 cells are usually produced in the fetus but may also arise later |
| Entered by | Uri M |
| ID | 102642 |