Size of macropinocytosis vesicles
| Range | 0.3-5 µm |
|---|---|
| Organism | Human Homo sapiens |
| Reference | Sallusto F, Cella M, Danieli C, Lanzavecchia A. Dendritic cells use macropinocytosis and the mannose receptor to concentrate macromolecules in the major histocompatibility complex class II compartment: downregulation by cytokines and bacterial products. J Exp Med. 1995 Aug 1 182(2):pp. 389PubMed ID7629501 |
| Comments | Antigens that fail to bind to cell surface receptors can still be taken up by fluid phase pinocytosis and presented by APCs, but with a much lower efficiency Fluid phase uptake can occur via distinct mechanisms (a) micropinocytosis, i.e., uptake of small vesicles via clathrin-coated pits and (b) macropinocytosis,i.e., uptake of large vesicles (0.5-3 µm) mediated by membrane ruffling driven by the actin cytoskeleton. |
| Entered by | Uri M |
| ID | 102637 |