Mutation rate per base pair per generation

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Value 2.5E-08 Mutation/bp/generation
Organism Human Homo sapiens
Reference Nachman MW, Crowell SL. Estimate of the mutation rate per nucleotide in humans. Genetics. 2000 Sep156(1):297-304.PubMed ID10978293
Method Researchers sequenced 18 processed pseudogenes in humans and chimpanzees, including 12 on autosomes and 6 on the X chromosome.
Comments Researchers suggest that 2.5×10^-8 is a reasonable estimate of the average mutation rate per nucleotide site (but caution that the actual rate may be between 1.3×10^-8 and 3.4×10^-8). The human diploid genome contains 7×10^9 bp (Marshall 1999) and thus ~175 new mutations per generation (range 91–238). Note that this value is for sexual generation. See BNID 105095 for rate of 5×10^-11 mutations/base pair/replication, BNID 100417. There is a 3 order of magnitude difference between mutation/bp/replication and mutation/bp/sexual generation as that is the number of cell divisions prior to sperm formation (there are ~400 cell divisions in a male of age 30 (Drost and Lee 1995 Vogel and Motulsky 1997)). For mutation per base pair per replication in E. coli see BNID 100263. See BNID 105813
Entered by Ron Milo - Admin
ID 100414