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ID104716
Property HeLa cell nucleus volume
Organism Human Homo sapiens
Value 690
Units µm^3
Reference Monier K, Armas JC, Etteldorf S, Ghazal P, Sullivan KF. Annexation of the interchromosomal space during viral infection. Nat Cell Biol. 2000 Sep2(9):661-5 Table - link
Reference PubMed ID 10980708
Method Researchers quantitatively monitored chromatin organization and chromosome dynamics in living cells after HSV-1 infection by using a fusion of histone H2B and green fluorescent protein (H2B–GFP)(ref 15). For volume measurements, confocal sections of individual nuclei from H2B–GFP HeLa cells either not infected or infected with HSV-1 were processed and analysed with 3-D image-analysis software (Ana3D© Y. Usson).
Comments Table gives volumes of nuclei of non-infected and infected Hela cells 8 and 9.5 hours after infection. 690 µm^3 is average of nucleus volume at these 2 time points. Researchers report direct quantitative analysis of the global structural perturbations of interphase chromosome and interchromosome domain distribution caused by infection with herpes simplex virus-1 (HSV-1). For nuclear volume of Hela cell in cervix tissue of 374 um^3 see BNID 101402
Entered By Uri M
Date Added Aug 07, 2009 10:11 AM
Date Edited Feb 03, 2010 7:25 AM
Version 3
Permalink http://bionumbers.hms.harvard.edu//bionumber.aspx?id=104716&ver=3
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