Diffusion coefficient of dense chromatin regions in the nucleus of HeLa cell

Value 4.8E-05 µm^2/sec
Organism Human Homo sapiens
Reference Görisch SM, Lichter P, Rippe K. Mobility of multi-subunit complexes in the nucleus: accessibility and dynamics of chromatin subcompartments.Histochem Cell Biol. 2005 Mar123(3):217-28 Table - link PubMed ID15830242
Primary Source Görisch SM, Wachsmuth M, Ittrich C, Bacher CP, Rippe K, Lichter P. Nuclear body movement is determined by chromatin accessibility and dynamics. Proc Natl Acad Sci U S A. 2004 Sep 7,101(36):13221-6.PubMed ID15331777
Method (Primary source) Fixation and Indirect Immunofluorescence. Confocal Laser Scanning and Correlative Electron Microscopy. Image Processing and Movement Analysis.
Comments Table gives corral size 'rc'-The size of the region in which a given particle or the chromatin locus can translocate its centre of mass during an observation time of up to a few minutes, defined by a circle with radius rc, and the diffusion coefficient within the corral. Corral radius=180 nm.
Entered by Uri M
ID 104287