Abstract
In vitro O2.- reduces Fe(III) to Fe(II), which, in turn, reduces the H2O2, yielding Fe(II)O or HO.. In vivo O2.- increases the supply of free iron by oxidatively attacking the [4Fe-4S] clusters of dehydratases such that they release Fe(II), which can then reduce H2O2. In vivo, O2.- also increases the production of H2O2 by acting as an oxidant toward the dehydratases and toward other cellular reductants.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Aconitate Hydratase / metabolism
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Ferrous Compounds / metabolism
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Free Radicals
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Hydro-Lyases / metabolism
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Hydrogen Peroxide / metabolism
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Hydroxyl Radical / metabolism*
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Iron-Sulfur Proteins / metabolism
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NADP / metabolism
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Oxidation-Reduction
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Superoxide Dismutase / metabolism
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Superoxides / pharmacology*
Substances
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Ferrous Compounds
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Free Radicals
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Iron-Sulfur Proteins
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Superoxides
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Hydroxyl Radical
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NADP
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Hydrogen Peroxide
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Superoxide Dismutase
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Hydro-Lyases
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Aconitate Hydratase