Abstract
Movement of ions across the cell membrane is driven by the free energy released from ATP hydrolysis. Here we will briefly review the chemistry of Na(+), K(+)-ATPase reaction; we will also review some recent results defining the relationship between the energetic driving force and Na(+) efflux by the Na(+) pump in the normal myocardium and then discuss this relationship for pathophysiologic states in the heart.
Publication types
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Research Support, N.I.H., Extramural
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Review
MeSH terms
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Adenosine Triphosphate / metabolism
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Animals
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Energy Metabolism / physiology*
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Heart / physiology*
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Homeostasis / physiology
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Humans
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Ion Channel Gating / physiology*
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Membrane Potentials / physiology
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Myocytes, Cardiac / physiology
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Signal Transduction / physiology*
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Sodium / metabolism*
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Sodium Channels / physiology*
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Sodium-Potassium-Exchanging ATPase / physiology*
Substances
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Sodium Channels
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Adenosine Triphosphate
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Sodium
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Sodium-Potassium-Exchanging ATPase