| Value |
2.7
unitless
|
| Organism |
Eukaryotes |
| Reference |
Watt IN, Montgomery MG, Runswick MJ, Leslie AG, Walker JE. Bioenergetic cost of making an adenosine triphosphate molecule in animal mitochondria. Proc Natl Acad Sci U S A. 2010 Sep 16PubMed ID20847295
|
| Method |
X ray diffraction data were collected
from the flash-frozen cryoprotected crystals at the Swiss Light Source
in the Paul Scherrer Institut, Villigen, Switzerland. The data were collected at
a wavelength of 1.0007 Å on beamline X06SA with a micro-diffractometer
and a MAR225 mosaic charge coupled detector (Rayonix). |
| Comments |
The most important inference from the
presence of the c8-ring in bovine F-ATP synthase, is that eight
protons are translocated across the inner mitochondrial membranes
per 360° rotation of its rotor. As each 360° rotation produces
three ATP molecules from the F1-domain, the bioenergetic
cost of the enzyme making an ATP is 2.7 protons. It appears that F-ATPases
in all vertebrates and probably all or most invertebrates, will
contain c8-rings. Therefore, the bioenergetic cost of the enzyme
making an ATP is 2.7 protons in vertebrates and probably in invertebrates
also (exceptions dictated by particular energetic
demands of a species may exist). |
| Entered by |
Burak Okumus |
| ID |
105661 |