Range |
≥3-4 weeks
|
Organism |
Unspecified |
Reference |
Santarelli L et al., Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants. Science. 2003 Aug 8 301(5634):805-9 DOI: 10.1126/science.1083328 p.805 left column top paragraphPubMed ID12907793
|
Primary Source |
[1] Wong ML, Licinio J. Research and treatment approaches to depression. Nat Rev Neurosci. 2001 May2(5):343-51 DOI: 10.1038/35072566PubMed ID11331918
|
Comments |
P.805 left column top paragraph: "But although ADs produce a rapid increase in extracellular levels of 5-HT [serotonin [5-hydroxytryptamine (5-HT)]] and NA [noradrenaline], the onset of an appreciable clinical effect usually takes at least 3 to 4 weeks (primary source). This delay suggests that slow neurochemical and structural changes take place within the limbic target areas of monoaminergic projections." |
Entered by |
Uri M |
ID |
117235 |