Composition of neurons of the striatum

Range medium spiny projection neurons (MSNs) 75-80%: four subtypes of interneurons together 20-25% % of striatal neurons
Organism Human Homo sapiens
Reference Ernst A et al., Neurogenesis in the striatum of the adult human brain. Cell. 2014 Feb 27 156(5):1072-83. doi: 10.1016/j.cell.2014.01.044 p.1075 right column 2nd paragraphPubMed ID24561062
Primary Source Cicchetti F, Prensa L, Wu Y, Parent A. Chemical anatomy of striatal interneurons in normal individuals and in patients with Huntington's disease. Brain Res Brain Res Rev. 2000 Nov34(1-2):80-101PubMed ID11086188
Method Primary source abstract: "This paper reviews the major anatomical and chemical features of the various types of interneurons in the human striatum, as detected by immunostaining procedures applied to postmortem tissue from normal individuals and patients with Huntington's disease (HD)."
Comments P.1075 right column 2nd paragraph: "The medium spiny projection neurons make up 75%–80% of the striatal neurons, and the four subtypes of interneurons together represent 20%–25% of the striatal neurons (primary source)."
Entered by Uri M
ID 117220