Onset of neurogenesis

Range ~11.5 embryonic day
Organism Mouse Mus musculus
Reference Rash BG, Lim HD, Breunig JJ, Vaccarino FM. FGF signaling expands embryonic cortical surface area by regulating Notch-dependent neurogenesis. J Neurosci. 2011 Oct 26 31(43):15604-17. doi: 10.1523/JNEUROSCI.4439-11.2011 p.15604 left column top paragraphPubMed ID22031906
Primary Source Takahashi T, Nowakowski RS, Caviness VS Jr. The leaving or Q fraction of the murine cerebral proliferative epithelium: a general model of neocortical neuronogenesis. J Neurosci. 1996 Oct 1 16(19):6183-96PubMed ID8815900
Comments P.15604 left column top paragraph: "In early cerebral cortical development most neuroepithelial progenitors undergo symmetric, self-replicative division, leading to a geometric expansion of the progenitor pool. However, the onset of neurogenesis at ∼E11.5 in the mouse (primary source) slows this expansion and begins to deplete neuronal progenitors as cortical neurons are born."
Entered by Uri M
ID 117214