| Range |
yeast >50 %: human >80 %
|
| Organism |
Eukaryotes |
| Reference |
Van Damme P et al., NatF contributes to an evolutionary shift in protein N-terminal acetylation and is important for normal chromosome segregation. PLoS Genet. 2011 Jul7(7):e1002169. doi: 10.1371/journal.pgen.1002169 p.2 left column 2nd paragraphPubMed ID21750686
|
| Primary Source |
[18] Arnesen T, Van Damme P, Polevoda B, Helsens K, Evjenth R, et al. (2009) Proteomics analyses reveal the evolutionary conservation and divergence of N-terminal acetyltransferases from yeast and humans. Proc Natl Acad Sci U S A 106: 8157–8162 doi: 10.1073/pnas.0901931106PubMed ID19420222
|
| Method |
Primary source abstract: "The COmbined FRActional DIagonal Chromatography (COFRADIC) proteomics technology that can be specifically used to isolate N-terminal peptides was used to determine the N-terminal acetylation status of 742 human and 379 yeast protein N termini, representing the largest eukaryotic dataset of N-terminal acetylation." |
| Comments |
P.2 left column 2nd paragraph: "N-Ac occurs on more than 50% and 80% of cytosolic yeast and human proteins, respectively [primary source]. The reason for the major difference in occurrence of N-Ac between yeast and humans to date is not known." Primary source abstract: "Overall, [investigators] observed a higher proportion of N-terminally acetylated proteins in humans (84%) as compared with yeast (57%)." |
| Entered by |
Uri M |
| ID |
116984 |