| Comments |
P.2/21 bottom paragraph:"Comparative genomic studies revealed that in fast-growing bacteria, essential genes involved in the expression of genetic information such as RNA polymerase (RNAP), ribosomal genes and specific tRNAs are found near oriC [ref 16]. In parallel, it has been observed that both
ribosome and RNA polymerase molecule counts can vary by one order of magnitude according to the cell physiological state, reaching its peak at the exponential phase. This is when the growth rate is maximal and bacteria need the highest synthesis capacity [ref 17]. In these circumstances, ribosomes account for 30% of the cell’s dry mass [BNID 112365]." |