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p.167 left column 3rd paragraph:"In mammals, the molecular oscillator uses interconnected transcriptional and translational feedback loops, in which multiple layers of control, including temporal posttranscriptional and posttranslational regulation, play important roles (ref 3). An active area of chronobiology aims at understanding how the temporal signals from the core oscillator are relayed to clock output function. In this context, genome-wide rhythms in mRNA accumulation were characterized in several models. In general, around 10% of the genes, encoding many enzymes involved in different aspects of cellular metabolism, show rhythmic mRNA accumulation, establishing the role of the circadian clock in temporally gating rhythmic physiology (primary source)." |