mutation rate and type in mutator strains (mutational landscape)
Range | Table - link mutation/gen# |
---|---|
Organism | Budding yeast Saccharomyces cerevisiae |
Reference | Serero A, Jubin C, Loeillet S, Legoix-Né P, Nicolas AG. (2014) Mutational landscape of yeast mutator strains, Proc Natl Acad Sci U S A.PubMed ID24449905 |
Method | Using NGS to find mutation rate and type after mutation accumulation experiment in yeast mutator strains pol32? and rad27? (replication), msh2? (mismatch repair, MMR), tsa1? (oxidative stress), mre11? (recombination), mec1? tel1? (DNA damage/S-phase checkpoints), pif1? (maintenance of the mitochondrial genome and telomere length), cac1? cac3? (nucleosome deposition), and clb5? (cell cycle progression)" |
Entered by | Dana BZ |
ID | 111191 |