| Primary Source |
Giegé, R., Jühling, F., Pütz, J., Stadler, P., Sauter, C., and Florentz, C. (2012) Structure of transfer RNAs: similarity and variability. Wiley Interdiscip Rev RNA 3: 37–61. & Jackman JE, Alfonzo JD. Transfer RNA modifications: nature's combinatorial chemistry playground. Wiley Interdiscip Rev RNA. 2013 Jan-Feb4(1):35-48. doi: 10.1002/wrna.1144.PubMed ID21957054, 23139145
|
| Comments |
"tRNAs bear the most chemically diverse modifications
among all types of nucleic acid entities: the presence of
modified nucleotides in tRNA is 10-fold more than in the
most abundant biological RNA, ribosomal RNAs (rRNAs),
and in total 17% of the tRNA nucleotides are modified
(primary sources). These
modifications play an important role and affect both structure and function of tRNAs. Modified nucleotides in the
anticodon loop and some more distant to the anticodon
loop affect the fidelity of decoding (Schmeing
et al
., 2011 & 2nd primary source). Modifications of nucleotides at position
34 alter the classical Watson-Crick pairing and allow one
tRNA species to read more than one codon (Crick, 1966
Agris, 1991 Agris
et al
.,2007)." |