| Range |
~2.5 (~9 μM) g/l
|
| Organism |
vertebrates |
| Reference |
Erickson HP. Size and shape of protein molecules at the nanometer level determined by sedimentation, gel filtration, and electron microscopy. Biol Proced Online. 2009 May 15 11: 32-51. doi: 10.1007/s12575-009-9008-x. p.35 2nd paragraphPubMed ID19495910
|
| Method |
"It is frequently useful to know the average volume of solution occupied
by each molecule, or more directly, the average distance
separating molecules in solution. This is a simple calculation based
only on the molar concentration.
In a 1-M solution, there are 6×10^23 molecules/l, = 0.6 molecules/nm^3, or inverting, the volume per molecule is V=1.66 nm^3/molecule at 1 M. For a concentration C, the volume
per molecule is V=1.66/C.
[Researchers] will take the cube root of the volume per molecule as an
indication of the average separation. d=V^(1/3)=1.18/C^(1/3), where C is in molar and d is in nanometer. Table 2 gives some typical values." |
| Comments |
"Fibrinogen is a large rod-shaped molecule that forms a fibrin
blood clot when activated. It circulates in plasma at a concentration
of around 2.5 g/l, about 9 µM. The fibrinogen molecules are
therefore about 60 nm apart [see measurement method], comparable to the 46-nm length of
the rod-shaped molecule." |
| Entered by |
Uri M |
| ID |
110543 |