| Range |
1.10 to 1.19 g/ml
|
| Organism |
Mammals |
| Reference |
Street et al., Identification and proteomic profiling of exosomes in human cerebrospinal fluid. J Transl Med. 2012 Jan 5 10(1):5. p.2 left column top paragraphPubMed ID22221959
|
| Primary Source |
[4] Keller et al., CD24 is a marker of exosomes secreted into urine and amniotic fluid. Kidney Int. 2007 Nov72(9):1095-102. DOI: 10.1038/sj.ki.5002486 [5] Graner et al., Proteomic and immunologic analyses of brain tumor exosomes. FASEB J. 2009 May23(5):1541-57 DOI: 10.1096/fj.08-122184PubMed ID17700640, 19109410
|
| Comments |
P.2 left column top paragraph: "Exosomes are lipid and protein rich vesicles that are formed as part of the intra-cellular endosomal pathway [ref 1]. During maturation of early endosomes into late endosomes within the cell, the endosomal limiting membrane undergoes invagination forming intra-luminal vesicles. A subset of endosomes fuse with the plasma membrane and their intra-luminal vesicles are released into the extracellular space where they are termed exosomes. Exosomes have physicochemical properties that distinguish them from other cell-derived vesicles. They are 20-100 nm in size [ref 2], appear cup-shaped when visualised by transmission electron microscopy (TEM) [ref 3], have a density of 1.10 to 1.19 g/ml [primary sources] and contain characteristic proteins that are central to their production [ref 6]." Please note, units of g/ml may be in error: primary source [4] gives units of mg/ml (p.1096 right column 4th paragraph & p.1098 right column). However, Tauro et al., 2012 PMID 22285593 p.294 right column top paragraph give buoyant flotation density in units of g/ml ("1.08–1.22 g/mL") |
| Entered by |
Uri M |
| ID |
107325 |