Transcripts of operons with average half-lives ≤2.5 minutes

Range Table - link Min
Organism Bacteria Escherichia coli
Reference Selinger DW, Saxena RM, Cheung KJ, Church GM, Rosenow C. Global RNA half-life analysis in Escherichia coli reveals positional patterns of transcript degradation. Genome Res. 2003 Feb13(2):216-23. p.217 table 2PubMed ID12566399
Method High-density oligonucleotide arrays from Affymetrix were used to study the degradation of RNA over essentially the entire transcriptome of E. coli MG1655. Average operon half-lives were calculated by taking the mean of the operons’ member ORFs for which half-lives had been determined.
Comments A number of the most unstable operons (Table 2) enable metabolism that is presumably unnecessary in rich media, such as amino acid biosynthesis (thr, cad), alternative carbon source catabolism (lac, sdh), and nucleotide biosynthesis (deo). See note beneath table
Entered by Uri M
ID 106874