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Affinity of ribonuclease inhibitor (RI) to blood vessel-inducing RNase angiogenin (ANG) (highest known protein-protein affinity)

Range	5E-16 to 7E-16 M
Organism	Mammals
Reference	Kumar K, Brady M, Shapiro R. Selective abolition of pancreatic RNase binding to its inhibitor protein. Proc Natl Acad Sci U S A. 2004 Jan 6 101(1):53-8 p.53 left column 2nd paragraphPubMed ID14681553
Primary Source	Lee FS, Shapiro R, Vallee BL. Tight-binding inhibition of angiogenin and ribonuclease A by placental ribonuclease inhibitor. Biochemistry. 1989 Jan 10 28(1):225-30. AND Shapiro R, Ruiz-Gutierrez M, Chen CZ. Analysis of the interactions of human ribonuclease inhibitor with angiogenin and ribonuclease A by mutagenesis: importance of inhibitor residues inside versus outside the C-terminal "hot spot". J Mol Biol. 2000 Sep 15 302(2):497-519PubMed ID2706246, 10970748
Entered by	Uri M
ID	106402