| Value |
0.024
mole ATP/gDW
|
| Organism |
Mouse LS cells |
| Reference |
Kilburn DG, Lilly MD, Webb FC. The energetics of mammalian cell growth. J Cell Sci. 1969 May4(3):645-54. p.651 bottom line continued p.652PubMed ID5817088
|
| Method |
The energy required to synthesize 1g dry weight of cells is the biosynthetic energy per cell times the number of cells per g, i.e. (1.6x10^-11)(1.5x10^9) = 0.024mole ATP |
| Comments |
The maximum possible YATP if no energy is used for maintenance is thus 1/0.024 =42g cells/mole ATP.
The biosynthesis of LS cells required 1.6 x 10^-11 moles
of ATP/cell. The maintenance energy, which is a function of growth rate, was 2.9 x 10^-11
moles ATP/new cell when the mean generation time was 1-15 days. The proportion of the
total energy used for maintenance under these conditions was 65 %. This corresponds to
a value of less than 10% for bacterial maintenance when the organisms are grown at near
their maximum rate. A comparison of biosynthetic energy requirements indicates that bacteria
and moulds require about 4 times as much energy as animal cells to generate the same weight
of cell material. |
| Entered by |
Uri M |
| ID |
106070 |