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Percent of total genome sequence targeted by microRNA

Range	1 - 5 %
Organism	Mammals
Reference	Jérôme T, Laurie P, Louis B, Pierre C. Enjoy the Silence: The Story of let-7 MicroRNA and Cancer. Curr Genomics. 2007 Jun8(4):p.232 left column top paragraphPubMed ID18645597
Primary Source	Bartel DP. MicroRNAs: genomics, biogenesis, mechanism, and function.MicroRNAs: genomics, biogenesis, mechanism, and function. Cell. 2004 Jan 23 116(2):281-97. & Bentwich et al., Identification of hundreds of conserved and nonconserved human microRNAs. Nat. Genet. 2005, 37: 766-770. & Berezikov, E., Guryev, V., van de Belt, J., Wienholds, E., Plasterk, R. H., Cuppen, E. Phylogenetic shadowing and computational identification of human microRNA genes. Cell 2005, 120: 21-24.PubMed ID14744438, 15965474, 15652478
Comments	"Now, miRNAs such as let-7 are estimated to comprise 1%–5% of the mammalian genome [primary sources], making them one of the most abundant classes of regulators."
Entered by	Uri M
ID	102290