The role of O2.- in the production of HO.: in vitro and in vivo

Free Radic Biol Med. 1994 Jan;16(1):29-33. doi: 10.1016/0891-5849(94)90239-9.

Abstract

In vitro O2.- reduces Fe(III) to Fe(II), which, in turn, reduces the H2O2, yielding Fe(II)O or HO.. In vivo O2.- increases the supply of free iron by oxidatively attacking the [4Fe-4S] clusters of dehydratases such that they release Fe(II), which can then reduce H2O2. In vivo, O2.- also increases the production of H2O2 by acting as an oxidant toward the dehydratases and toward other cellular reductants.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aconitate Hydratase / metabolism
  • Ferrous Compounds / metabolism
  • Free Radicals
  • Hydro-Lyases / metabolism
  • Hydrogen Peroxide / metabolism
  • Hydroxyl Radical / metabolism*
  • Iron-Sulfur Proteins / metabolism
  • NADP / metabolism
  • Oxidation-Reduction
  • Superoxide Dismutase / metabolism
  • Superoxides / pharmacology*

Substances

  • Ferrous Compounds
  • Free Radicals
  • Iron-Sulfur Proteins
  • Superoxides
  • Hydroxyl Radical
  • NADP
  • Hydrogen Peroxide
  • Superoxide Dismutase
  • Hydro-Lyases
  • Aconitate Hydratase