Determinant of cistron specificity in bacterial ribosomes

Nature. 1975 Mar 6;254(5495):34-8. doi: 10.1038/254034a0.

Abstract

The sequence of the 3'-terminus of 16S RNA from different bacteria has been determined. Complementarity relationships between this sequence and a purine-rich tract in the ribosome binding site of different bacterial mRNAs suggest that the 3'-end of 16S RNA determines the intrinsic capacity of ribosomes to translate a particular cistron.

MeSH terms

  • Bacillus
  • Base Sequence
  • Binding Sites
  • Coliphages
  • Escherichia coli
  • Genes*
  • Genetic Code
  • Peptide Initiation Factors
  • Protein Biosynthesis*
  • Pseudomonas aeruginosa
  • RNA, Bacterial / metabolism*
  • RNA, Ribosomal / metabolism*
  • Ribosomes / metabolism
  • Species Specificity

Substances

  • Peptide Initiation Factors
  • RNA, Bacterial
  • RNA, Ribosomal