Dynamic systems modeling is a method to study systematic properties of a complex system. The basic principles, procedures, and tools available to develop a dynamic systems model of complex metabolic processes are detailed. Here, a photosynthetic carbon metabolism model, which includes the Calvin Benson cycle, photorespiration, and starch and sucrose synthesis pathways, is used as an example to illustrate the whole process of model development.
Keywords: Dynamic systems modeling; Model validation; Modularized design; Optimization; Ordinary differential equations; Parameter estimation; Sensitivity analysis.