Fragment deconstruction of small, potent factor Xa inhibitors: exploring the superadditivity energetics of fragment linking in protein-ligand complexes

MeSH terms

• Amides / chemistry
• Binding Sites
• Crystallography, X-Ray
• Factor Xa / metabolism
• Factor Xa Inhibitors*
• Ligands*
• Protein Structure, Tertiary
• Serine Proteinase Inhibitors / chemistry*
• Thermodynamics