Physically separated references for diffusion coefficient-formula weight (D-FW) analysis of diffusion-ordered NMR spectroscopy (DOSY) in water

Weibin Li; Gerald Kagan; Huan Yang; Chen Cai; Russell Hopson; Dwight A Sweigart; Paul G Williard

doi:10.1021/ol100686e

Physically separated references for diffusion coefficient-formula weight (D-FW) analysis of diffusion-ordered NMR spectroscopy (DOSY) in water

Org Lett. 2010 Jun 18;12(12):2698-701. doi: 10.1021/ol100686e.

Authors

Weibin Li¹, Gerald Kagan, Huan Yang, Chen Cai, Russell Hopson, Dwight A Sweigart, Paul G Williard

Affiliation

¹ Department of Chemistry, Brown University Providence, Rhode Island 02912, USA.

PMID: 20481557
DOI: 10.1021/ol100686e

Abstract

Development and application of physically separated references for aqueous (1)H DOSY diffusion coefficient-formula weight (D-FW) correlation analysis is reported. Commercially available biological buffers (Tris and HEPES) and a water-soluble alcohol (tert-butanol) were used as physically separated references for a Ru and a Mn complex in D(2)O. This extension of DOSY D-FW analysis expands its applicability to a wide variety of water-soluble molecules or metal complexes, with particular application to green chemistry.