Influence of catabolite repression and inducer exclusion on the bistable behavior of the lac operon

Biophys J. 2004 Mar;86(3):1282-92. doi: 10.1016/S0006-3495(04)74202-2.

Abstract

A mathematical model of the lac operon which includes all of the known regulatory mechanisms, including external-glucose-dependent catabolite repression and inducer exclusion, as well as the time delays inherent to transcription and translation, is presented. With this model we investigate the influence of external glucose, by means of catabolite repression and the regulation of lactose uptake, on the bistable behavior of this system.

Publication types

  • Comparative Study
  • Evaluation Study
  • Research Support, Non-U.S. Gov't
  • Validation Study

MeSH terms

  • Catalysis
  • Computer Simulation
  • Cyclic AMP Receptor Protein / genetics
  • Cyclic AMP Receptor Protein / metabolism*
  • Escherichia coli / genetics
  • Escherichia coli / metabolism
  • Gene Expression Regulation, Bacterial / physiology*
  • Glucose / genetics
  • Glucose / metabolism*
  • Homeostasis / physiology
  • Lac Operon / physiology*
  • Lactose / genetics
  • Lactose / metabolism*
  • Models, Biological*
  • Promoter Regions, Genetic / genetics
  • beta-Galactosidase / genetics
  • beta-Galactosidase / metabolism*

Substances

  • Cyclic AMP Receptor Protein
  • beta-Galactosidase
  • Glucose
  • Lactose