O2 (oxygen) diffusion coefficients through high density [11% and 34%] collagen type I scaffolds (see Method section for photochemically crosslinked collagen scaffold at 11%))

Range 450 for 11% density collagen scaffolds: 170 for 34% collagen scaffolds µm^2/sec
Organism Generic
Reference Cheema U et al., Oxygen diffusion through collagen scaffolds at defined densities: implications for cell survival in tissue models. J Tissue Eng Regen Med. 2012 Jan6(1):77-84. doi: 10.1002/term.402 abstractPubMed ID21312340
Method Abstract: "[Investigators] have established O(2) diffusion coefficients through native, dense collagen scaffolds at two tissue-like densities, with and without photo-chemical crosslinking, by adapting an optical fibre-based system for real-time core O(2) monitoring deep within collagen constructs. Using a Fick's law model, [they] then derived O(2) diffusion coefficients 4.5 × 10^(-6) cm^(2) /s for 11% density collagen scaffolds, 1.7 × 10^(-6) cm^(2) /s for 34% collagen scaffolds, 3.4 × 10(-6) cm(2) /s for photochemically crosslinked collagen scaffolds at 11%."
Entered by Uri M
ID 115120