Fraction of increase in energy expenditure (EE) when body temperature rises by 1˚C (for alternative values see comments section)

Value 16 % per 1˚C
Organism Human Homo sapiens
Reference Benhariz M, Goulet O, Salas J, Colomb V, Ricour C. Energy cost of fever in children on total parenteral nutrition. Clin Nutr. 1997 Oct16(5):251-5 p.254 right column 2nd paragraph and bottom paragraphPubMed ID16844604
Method P.252 left column bottom paragraph: "Oxygen consumption (VO2) and carbon dioxide production (VCO2) were measured by using indirect calorimetry (MMC Horizon, Beckman ®, Sensor Medics ®, Anaheim, CA, USA) with a ventilated hood system. Calibration was performed before each test, once with a mixture of O2 and CO2 of known concentration and secondly with pure nitrogen. In addition, quality control of the apparatus was achieved by infusion of pure nitrogen, simulating O2 consumption and combustion of ethyl alcohol at 99.7%±0.2 (Carlo Erba®-Milan) as the control of respiratory quotient."
Comments P.254 right column top of 2nd paragraph: "In this study, the rise of EE (Energy Expenditure) and that of the axillary [arm-pit] temperature are correlated. The slope of regression line (16%/1°C) represents the fraction of the rise in EE related to fever. In the Stettler et al study (ref 4) this fraction is equal to 6.9%, while it is 13% in the Dubois study (ref 1). This difference could be due to the different populations in each study. The small number of children in [investigators’] study might also account for this difference." P.254 right column bottom of 2nd paragraph: "By dividing the individual rise of EE by the individual rise of temperature, EE increase is equal to 11.3% for 1°C of temperature. This result is close to those reported by Dubois et al (ref 1) and Stettler et al (ref 4) but differs from those of a recent study performed in sick infants less than one year of age (ref 5)." P.254 right column bottom paragraph: "In conclusion, in this pediatric population parenterally fed, fever is responsible for an EE rise of 16% per degree of fever. Protracted fever due to infection or inflammatory process is partly responsible for an hypermetabolic state including increased energy expenditure and protein breakdown."
Entered by Uri M
ID 115049