Fraction of all free fatty acids in the circulation

Range Oleic acid, palmitic acid & stearic acid ~78% Linoleic acid & arachidonic acid ~8% %
Organism Human Homo sapiens
Reference Quehenberger et al., Lipidomics reveals a remarkable diversity of lipids in human plasma. J Lipid Res. 2010 Nov51(11):3299-305. doi: 10.1194/jlr.M009449. p.3300 right column bottom paragraphPubMed ID20671299
Method "The LIPID MAPS Consortium has developed innovative lipidomics techniques based on liquid chromatography coupled to mass spectroscopy to probe biological systems (3) and has undertaken the task of analyzing the NIDDK [The National Institute of Diabetes and Digestive and Kidney Diseases]/ NIST [National Institute of Standards] SRM [standard reference material] by systematically identifying and quantifying the lipid molecular species of the mammalian lipidome (5, 6)."
Comments "As shown in Table 1 - link and supplementary Table IA - link human plasma of healthy individuals after overnight fasting contains an average of 214 nmol/ml of free fatty acids. Oleic acid (18:1) is the major constituent followed by palmitic acid (16:0) and stearic acid (18:0) (supplementary Table IA ). Together, these three species comprise about 78% of all free fatty acids in the circulation. Linoleic acid (18:2) and arachidonic acid (20:4) are the main PUFAs [Polyunsaturated fatty acids] (about 8% of the total), but the nutritionally essential a-linolenic acid (18:3?-3), eicosapentaenoic acid (20:5, EPA), and docosahexaenoic acid (22:6, DHA) are also present at significant levels, together making up about 1% of all free fatty acids."
Entered by Uri M
ID 110990