Size of aggregosome

Range 2-10 Table - link µm
Organism Generic
Reference Spector DL. SnapShot: Cellular bodies. Cell. 2006 Dec 1127(5):1071PubMed ID17129789
Primary Source Johnston JA, Ward CL, Kopito RR. Aggresomes: a cellular response to misfolded proteins. J Cell Biol. 1998 Dec 28143(7):1883-98PubMed ID9864362
Method Primary source abstract: "Using immunofluorescence and transmission electron microscopy with immunogold labeling, Resesarchers demonstrate that undegraded CFTR molecules accumulate at a distinct pericentriolar structure which they have termed the aggresome."
Comments Primary source abstract: "Aggresome formation is accompanied by redistribution of the intermediate filament protein vimentin to form a cage surrounding a pericentriolar core of aggregated, ubiquitinated protein."
Entered by Uri M
ID 104581