Number of EGFR copies in a HeLa cell

Value 50000 copies/cell Range: 30000-80000 Table - link copies/cell
Organism Human Homo sapiens
Reference Schoeberl B, Eichler-Jonsson C, Gilles ED, Müller G. Computational modeling of the dynamics of the MAP kinase cascade activated by surface and internalized EGF receptors. Nat Biotechnol. 2002 Apr20(4):370-5 Supplementary table 2PubMed ID11923843
Primary Source 1) Wiley HS. Anomalous binding of epidermal growth factor to A431 cells is due to the effect of high receptor densities and a saturable endocytic system. J Cell Biol. 1988 Aug107(2):801-10. (2) Berkers JA, van Bergen en Henegouwen PM, Boonstra J. Three classes of epidermal growth factor receptors on HeLa cells. J Biol Chem. 1991 Jan 15 266(2):922-7.PubMed ID3262110, 1985972
Method Average of values given by Primary sources (1) and (2)
Comments Please see EGFR copy number in Rat fetal liver cell: 2.5E4 copies/cell, BNID 101358 Table - link
Entered by Uri M
ID 104829