Transit time of amino acid molecule from granular to surface epidermis

Range mouse ~5: human 24.5 Table - link days
Organism Mammals
Reference Potten CS, Saffhill R, Maibach HI. Measurement of the transit time for cells through the epidermis and stratum corneum of the mouse and guinea-pig. Cell Tissue Kinet. 1987 Sep20(5):461-72 abstract and p.469 figure 5PubMed ID3450396
Method Abstract: "A new approach to determine the transit time through the epidermis is presented, involving a gentle washing of the skin surface to collect the loosely attached surface corneocytes. This, it is believed, will be less likely to stimulate the system than tape-stripping or scraping. Radioactively labelled thymidine and iododeoxyuridine have been used to label cells in the basal layer and various labelled amino acids (glycine, cystine and methionine) have been used to label the metabolically viable cell layers (up to and including the granular layer)."
Comments Abstract: "The granular to surface time in mice is about 5 days." P.469 figure 5: Range for mouse is 4-6 days. Range for human is 21-28 days
Entered by Uri M
ID 115445