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||Park JO et al., Metabolite concentrations, fluxes and free energies imply efficient enzyme usage. Nat Chem Biol. 2016 May 2. doi: 10.1038/nchembio.2077. Supplementary Information p.5 Supplementary Table 3PubMed ID27159581
||Abstract: "Here [investigators] use isotope labeling to measure absolute metabolite concentrations and fluxes in Escherichia coli, yeast and a mammalian cell line. [They] then integrate this information to obtain a unified set of concentrations and ΔG for each organism."
||P.3 left column top paragraph: "Metabolite sets were penalized when either concentrations or free energies fell outside of the 95% confidence intervals of the measurements. [Investigators] subsequently obtained upper and lower boundaries for metabolite concentrations and reaction free energies by linear programming. This approach identified previously unmeasured absolute metabolite concentrations and more tightly constrained those of metabolites that were involved in multiple reactions with measured cellular ΔG values (for example, DHAP and pentose phosphates)
(Fig. 4a and Supplementary Table 3)." iBMK=Immortalized Baby Mouse Kidney Epithelial Cells