Percent of all RNAPs that are nonspecifically-bound to DNA

Range at 0.6 doublings/hour 75%: at 2.5 doublings/hour 54% %
Organism Bacteria Escherichia coli
Reference Klumpp S, Hwa T. Growth-rate-dependent partitioning of RNA polymerases in bacteria. Proc Natl Acad Sci U S A. 2008 Dec 23 105(51):20245-50. doi: 10.1073/pnas.0804953105. p.20247 left column bottom paragraphPubMed ID19073937
Comments "For all growth rates, nonspecific binding to DNA (blue triangles, fig S3) is predicted to make up the largest fraction of RNAPs, despite the fact that nonspecific binding is very weak. Nonspecific binding accounts for 75% of all RNAPs at slow growth (0.6 doubling per hour). This fraction decreases to 54% at 2.5 doublings per hour."
Entered by Uri M
ID 110065