Fraction of evolutionarily constrained sequences in the genome that have experimental evidence of function

Value 60 %
Organism Human Homo sapiens
Reference ENCODE Project Consortium, Birney E et al., Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project. Nature. 2007 Jun 14 447(7146):799-816. p.800 left columnPubMed ID18514361
Method For methods see table 1 p.801 Table - link
Comments A total of 5% of the bases in the genome can be confidently identified as being under evolutionary constraint in mammals for approximately 60% of these constrained bases, there is evidence of function based on the results of the experimental assays performed to date. Please note that a 1% sample of the human genome was analyzed. ENCODE=the ENCyclopedia Of DNA Elements
Entered by Uri M
ID 105748