Relevant examples of aptamer molecular beacons application targets, signal recorded and concentration range

Range Table - link
Organism Unspecified
Reference Mairal T, Ozalp VC, Lozano Sánchez P, Mir M, Katakis I, O'Sullivan CK. Aptamers: molecular tools for analytical applications. Anal Bioanal Chem. 2008 Feb390(4):989-1007.PubMed ID17581746
Primary Source Pointers to refs in table
Method FRET (fluorescence resonance energy transfer) and fluorescence quenching
Comments Aptamers are artificial nucleic acid ligands, specifically generated against certain targets, such as amino acids, drugs, proteins or other molecules. A molecular beacon was first reported by Tyagi et al 1996 PMID 9630890, who defined them as “nucleic acids probes able to undergo spontaneous conformational change, after hybridising their complementary nucleic acid targets, translated into a change in their fluorogenic properties”.
Entered by Uri M
ID 105438