Abundance of some key cell cycle proteins

Range Table - link proteins/cell
Organism Budding yeast Saccharomyces cerevisiae
Reference Oguz C et al., A stochastic model correctly predicts changes in budding yeast cell cycle dynamics upon periodic expression of CLN2. PLoS One. 2014 May 9 9(5):e96726. doi: 10.1371/journal.pone.0096726. Supporting Information table S8PubMed ID24816736
Method Abstract:"First, [investigators] estimate the model parameters using extensive data sets: phenotypes of 110 genetic strains, single cell statistics of wild type and cln3 strains. Optimization of stochastic model parameters is achieved by an automated algorithm [they] recently used for a deterministic cell cycle model. Next, in order to test the predictive ability of the stochastic model, [they] focus on a recent experimental study in which forced periodic expression of CLN2 cyclin (driven by MET3 promoter in cln3 background) has been used to synchronize budding yeast cell colonies."
Comments P.3 right column top paragraph:"[Investigators] also capture the abundances of key cell cycle proteins within threefold of experimental values [ref 15], [ref 16] as shown in Table S8. In addition, [they] note that the stochastic simulation statistics presented in Tables 1, 2, and S8 have coefficient of variation (CV) values of less than 10% (low variability) among 15 independent realizations." See note and ref beneath table
Entered by Uri M
ID 112259