| Range |
men 12.9×10^8synapses/mm^3: women 8.6×10^8synapses/mm^3 synapses/mm^3
|
| Organism |
Human Homo sapiens |
| Reference |
Alonso-Nanclares L, Gonzalez-Soriano J, Rodriguez JR, DeFelipe J. Gender differences in human cortical synaptic density. Proc Natl Acad Sci U S A. 2008 Sep 23 105(38):14615-9. doi: 10.1073/pnas.0803652105. p.14616 right column 3rd paragraphPubMed ID18779570
|
| Method |
P.14615 right column 3rd paragraph:"Light Microscopy Analysis: [Investigators] analyzed the thickness and neuronal density in layers I, II, IIIA, IIIB, IV, V, and VI of 100-µm Nissl-stained sections from the tissue obtained. No significant differences were found between men and women regarding the neuronal density (Table 1 and Fig. 1A) as previously reported in the temporal neocortex (ref 13)." |
| Comments |
P.14616 right column 3rd paragraph:"Synapses were quantified in the neuropil (i.e., avoiding the
neuronal and glial somata, blood vessels, large dendrites, and
myelinated axons) (ref 23), and [investigators] found men to have a higher
synaptic density in all layers (Fig. 1C). The smallest difference in
density was found in layer II, in which the synaptic density was
18% higher in men than in women (Fig. 1C), whereas the
greatest difference was found in layer V, where the synaptic
density in men was 52% higher than in women (678 million
synapses per cubic millimeter plus). Considering all layers, men
also have a significant higher average synaptic density of 12.9×10^8 per cubic millimeter, whereas in women it was 8.6×10^8 per
cubic millimeter. Thus, there was a 33% difference in synaptic
density between men and women." |
| Entered by |
Uri M |
| ID |
112052 |