Synaptic density considering all cortical layers

Range men 12.9×10^8synapses/mm^3: women 8.6×10^8synapses/mm^3 synapses/mm^3
Organism Human Homo sapiens
Reference Alonso-Nanclares L, Gonzalez-Soriano J, Rodriguez JR, DeFelipe J. Gender differences in human cortical synaptic density. Proc Natl Acad Sci U S A. 2008 Sep 23 105(38):14615-9. doi: 10.1073/pnas.0803652105. p.14616 right column 3rd paragraphPubMed ID18779570
Method P.14615 right column 3rd paragraph:"Light Microscopy Analysis: [Investigators] analyzed the thickness and neuronal density in layers I, II, IIIA, IIIB, IV, V, and VI of 100-µm Nissl-stained sections from the tissue obtained. No significant differences were found between men and women regarding the neuronal density (Table 1 and Fig. 1A) as previously reported in the temporal neocortex (ref 13)."
Comments P.14616 right column 3rd paragraph:"Synapses were quantified in the neuropil (i.e., avoiding the neuronal and glial somata, blood vessels, large dendrites, and myelinated axons) (ref 23), and [investigators] found men to have a higher synaptic density in all layers (Fig. 1C). The smallest difference in density was found in layer II, in which the synaptic density was 18% higher in men than in women (Fig. 1C), whereas the greatest difference was found in layer V, where the synaptic density in men was 52% higher than in women (678 million synapses per cubic millimeter plus). Considering all layers, men also have a significant higher average synaptic density of 12.9×10^8 per cubic millimeter, whereas in women it was 8.6×10^8 per cubic millimeter. Thus, there was a 33% difference in synaptic density between men and women."
Entered by Uri M
ID 112052